Hi,
Same issue occurred on DS 4.2 SP 7, I solved it as below steps
1. Run ODBCDriverSelector.exe . (it is under installDir\DataServices\bin)
2. For all Sybase Anywhere Database versions select SQL Anywhere 16 or which driver installed on your server.
3. in DataServices Server management tool: resync your repository which are added jobserver and restart jobserver.
you can use Tony's solution but in that case you must create ODBC connection for all clients.
Sinan